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Novel gene-searching software improves accuracy in disease studies

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Jan. 22, 2013 — A novel software tool, developed at The Children's Hospital of Philadelphia, streamlines the detection of disease-causing genetic changes through more sensitive detection methods and by automatically correcting for variations that reduce the accuracy of results in conventional software. The software, called ParseCNV, is freely available to the scientific-academic community, and significantly advances the identification of gene variants associated with genetic diseases.

"The algorithm we developed detects copy number variation associations with a higher level of accuracy than that available in existing software," said the lead inventor of ParseCNV, Joseph T. Glessner, of the Center for Applied Genomics at The...

Soft nanoscale 'Lego' built in the computer

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Simulation snapshot of a cubic crystal built of soft patchy diblock star polymers. (Credit: Copyright American Physical Society)

Jan. 17, 2013 — Barbara Capone of the Computational Physics Group of the University of Vienna has developed a new method for the construction of building blocks at the nanoscale. The researcher in Soft Matter Physics, who works at the group of Christos Likos, Professor for Multiscale Computational Physics, has specialized in the...

When will genomic research translate into clinical care -- and at what cost? New study applies quantitative modeling to genomics

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Jan. 4, 2013 — Genomic research is widely expected to transform medicine, but progress has been slower than expected. While critics argue that the genomics "promise" has been broken -- and that money might be better spent elsewhere -- proponents say the deliberate pace underscores the complexity of the relationship between medicine and disease and, indeed, argues for more funding.

But thus far, these competing narratives have been based mostly on anecdotes. Ramy Arnaout, MD...

Toward a new model of the cell: Everything you always wanted to know about genes

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This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. (Credit: UC San Diego School of Medicine)

Dec. 16, 2012 — Turning vast amounts of genomic data into meaningful information about the cell is the great challenge of bioinformatics, with major implications for human biology and medicine. Researchers at the University of California, San Diego School of Medicine and colleagues have proposed a new...

Best of both worlds: Hybrid approach sheds light on crystal structure solution

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With traditional crystal structure solution techniques, light atoms such as the hydrogen present in MgNH (above) often remain largely invisible, their positions unknown. A new method developed by Northwestern University researchers illuminates such elusive atoms with first-principles-based structural optimization. (Credit: Art credit: Robert Hodgin)

Dec. 11, 2012 — Understanding the arrangement of atoms in a solid -- one of solids' fundamental properties -- is vital...