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Identifying aggressive breast cancers by interpreting the mathematical patterns in the cancer genome

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TechAndComputer (Aug. 23, 2012) — It is now possible to identify aggressive breast cancers by interpreting the mathematical patterns in the cancer genome.


Researchers at the University of Oslo, Norway (UiO) have developed a completely new method for differentiating between breast cancer patients with high and low risks of dying from the illness.

'Current methods cannot predict who will do well and who will not. We have wanted to identify the very seriously ill patients so that they can receive aggressive treatment', says Hege Russnes at the Department of Pathology and the Department of Medical Genetics at the Oslo University Hospital and UiO.

To be on the safe side, many breast cancer patients are treated unnecessarily with...

New computational technique relieves logjam from massive amounts of data

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TechAndComputer (Aug. 1, 2012) — It's relatively easy to collect massive amounts of data on microbes. But the files are so large that it takes days to simply transmit them to other researchers and months to analyze once they are received. Share This: See Also: Plants & AnimalsSoil TypesSpiders and TicksFungusComputers & MathInformation TechnologyHackingEncryptionReference Computational genomicsBioinformaticsComputingList of data...

Knee stress studied at tissue, cellular levels

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TechAndComputer (July 24, 2012) — A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads -- virtual models that someday can be used to understand damage mechanisms caused by the aging process or debilitating diseases, such as osteoarthritis.

Led by Ahmet Erdemir, Ph.D., the team is leveraging the powerful computing systems of the Ohio Supercomputer Center to develop...

Evolutionary information improves discovery of mutations associated with diseases

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TechAndComputer (July 17, 2012) — A book containing misprints may cause annoyance for the reader, but typos in an individual's genetic blueprint (DNA) can mean serious disease or even death. The search for genetic correlates for the wide range of diseases plaguing humankind has inspired a wealth of research falling under the heading of genome-wide association studies (GWAS).

According to Sudhir Kumar, director of the Center for Evolutionary Medicine and Informatics at Arizona...

New tools facilitate matching cancer drugs with gene targets

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TechAndComputer (July 16, 2012) — A new study details how a suite of web-based tools provides the research community with greatly improved capacity to compare data derived from large collections of genomic information against thousands of drugs. By comparing drugs and genetic targets, researchers can more easily identify pharmaceuticals that could be effective against different forms of cancer.

The newly updated software, called CellMiner, was built for use with the NCI-60, one...